The Benefits of L-Citruline Malate

Dr Francesca Alves, PhD

L-Citrulline Malate is a compound that combines L-citrulline, a non-essential amino acid, with malate, a derivative of malic acid. Combining L-Citrulline with malate (malic acid) in the form of L-Citrulline Malate is believed to enhance the benefits of both components. But first, let's break down the individual molecular benefits.

L-citrulline: Once ingested, L-Citrulline is converted into L-arginine in the kidneys. L-arginine is a precursor for nitric oxide synthesis and is utilized by the enzyme nitric oxide synthase (NOS) to produce nitric oxide. Increased NO levels lead to vasodilation, which improves blood flow and nutrient delivery to tissues, especially muscles. L-Citrulline also helps in the urea cycle by detoxifying ammonia, a byproduct of protein metabolism. Lower ammonia levels reduce muscle fatigue and promote better endurance. Increased blood flow and waste removal can have an immediate benefit on performance. Indeed, several studies have shown an acute benefit of maximum output after ingesting 4-10 grams of citrate malate approximately 1 hour before exercising1-4.

Malate: Malate is an intermediate in the citric acid cycle (Krebs cycle), which is crucial for the production of ATP, the primary energy currency of the cell. Indeed, in one study using the same dose present in Stimul8 (6g), citrate malate ingestion resulted in a significant reduction in the sensation of fatigue and a 34% increase in the rate of oxidative ATP production during exercise5.

In summary, synergizing L-Citrulline with malate (malic acid) in the form of L-Citrulline Malate is believed to enhance the benefits of both components. The combination of increased blood flow and metabolic waste removal with an energy resource can help improve energy production during exercise, leading to enhanced performance and reduced fatigue.